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Pickart and colleagues (Biomed Res Int, 2015) published a comprehensive genome-wide analysis documenting effects on DNA repair pathways (with multiple repair-enzyme genes upregulated, including those involved in nucleotide excision repair and base excision repair), anti-oxidant systems (modulation of superoxide dismutase, catalase, and glutathione-related genes), matrix-remodeling pathways (collagen, elastin, and proteoglycan synthesis enzymes), and inflammatory pathway markers

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Judah Folkman leaves expanding legacy