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Adipocyte energy expenditure and reduced lipogenesis In differentiating 3T3-L1 pre-adipocytes, 30 µM and 60 µM 5-Amino-1MQ reduced lipid accumulation by 50% and 70% respectively against untreated controls, with cell viability only slightly reduced at the highest concentration tested

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The ferroptosis inhibitor sulfasalazine (SSZ) enhances ferroptosis by blocking SLC7A11 and stimulating the lipoxygenase ALOX ( Figure 2 ) (103)