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109 Mice with genetically obesity treated with DFO exhibited a decrease in hepatic steatosis and an improvement in hepatic lipid accumulation along with an increased expression of proteins, such as uncoupling protein 1 (UCP-1), peroxisome proliferator-activated receptor gamma (PPARγ), and PPARγ coactivator-1alpha (PGC-1α) 109 Meanwhile, Xue et al., 109 found that DFO treatment significantly reduced hepatic cell apoptosis, liver inflammation, and oxidative stress in ob/ob mice