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Best Peptides to Stack with IGF-1 LR3 “GH secretagogues like CJC-1295 and Ipamorelin increase plasma GH and IGF-1 levels, mimicking natural hormone pulses while reducing side effects.” — Merriam et al., Endocrinology and Metabolism Clinics Sample Peptide Stack Protocol with IGF-1 LR3 Goal: Muscle growth, fat loss, and joint recovery IGF-1 LR3 – 40–80 mcg per day (post-workout or split AM/PM) CJC-1295 w/ DAC – 2 mg once weekly Ipamorelin – 100 mcg 2–3x daily (AM, pre-bed, post-training) TB-500 – 2–5 mg weekly (split dose) BPC-157 – 250–500 mcg 1–2x daily for site-specific healing Note: Peptide timing should support circadian rhythm, with GH secretagogues ideally used pre-bed or post-training for maximum recovery
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The FDA's July 2026 briefing document, prepared for its Pharmacy Compounding Advisory Committee, evaluated BPC-157 only for ulcerative colitis, found five clinical studies (all rectal enema or similar), and noted that in the studies with blood sampling the drug was not detected in plasma