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Mechanistic comparison: TB-500 primarily functions through actin binding and modulation of cell motility, with additional effects on PI3K/Akt/eNOS signaling, anti-inflammatory pathways, and antifibrotic activity

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Then there is the Bcl-2-associated X protein(Bax) subfamily, which has pro-apoptotic activity and can form holes within the mitochondrial membrane (80), resulting in mitochondrial outer membrane permeabilization (MOMP) as well as a short discharge of cytochrome c (81, 82)