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By stripping the molecule down to its terminal three residues, researchers hoped to keep the anti-inflammatory tail while discarding the receptor-driven pigmentation — and the colitis data suggest that at least some of KPV’s activity runs through a receptor-independent, transporter-mediated route rather than classic melanocortin signaling

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Caballero, Marta Pérez-Hernández, Vanessa Soto-Cerrato, Luís Korrodi-Gregório, Ricardo Pérez-Tomás, Maria Michela Dell'Anna, Piero Mastrorilli, Patrick Gamez Journal of Inorganic Biochemistry.2019