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Additionally, the unique characteristics of these nanocarriers, such as their small size (10-1000 nm), surface properties (charge, hydrophobicity), and ability to incorporate targeting ligands, facilitate their penetration through the stratum corneum, the outermost layer of the skin

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In terms of future research directions, large-scale, randomized, placebo-controlled clinical trials must be conducted that fully consider the effects of potential confounding factors to clarify the long-term effects of SSRIs on male and female fertility, to assess the recovery of reproductive function after drug discontinuation, and to clarify their reversibility

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